Harnessing the power of computational chemical biology to address non-traditional drug targets

Welcome to the Karanicolas Lab! Our goal is to develop structure-based approaches for modulating protein function using small-molecules. We apply these new approaches in projects seeking to re-activate disabled tumor suppressors, inhibit cancer-driving RNA-binding proteins, disable key oncogenic kinases, and tune the activity of antibodies used in cancer immunotherapy.



John Karanicolas Promoted to Full Professor

PHILADELPHIA (August 21, 2019) – John Karanicolas, PhD, was recently promoted to the rank of Professor at Fox Chase Cancer Center. Reviewers highlighted the fact that his research program is among the most innovative in computer-aided drug design in the United States, and that he serves as an outstanding mentor.

John Karanicolas Receives Grant from the National Science Foundation

PHILADELPHIA (October 30, 2018) – John Karanicolas, PhD, an associate professor at Fox Chase Cancer Center, has received a grant from the National Science Foundation to conduct deep learning to design selective kinase-targeted chemical probes. Read More